2019 Breakthrough Articles

Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins

Michael T. Migawa, Wen Shen, W. Brad Wan, Guillermo Vasquez, Michael E. Oestergaard, Audrey Low, Cheryl L. De Hoyos, Ruchi Gupta, Susan Murray, Michael Tanowitz, Melanie Bell, Joshua G. Nichols, Hans Gaus, Xue-hai Liang , Eric E. Swayze, Stanley T. Crooke and Punit P. Seth

Nucleic Acids Res (2019) 47(11): 5465–5479. doi:10.1093/nar/gkz247