2022 Breakthrough Articles

Dissection of the Caenorhabditis elegans Microprocessor

Thuy Linh Nguyen, Trung Duc Nguyen, Minh Khoa Ngo, Tuan Anh Nguyen

Nucleic Acids Research, gkac1170, https://doi.org/10.1093/nar/gkac1170

A scanning-to-incision switch in TFIIH-XPG induced by DNA damage licenses nucleotide excision repair

Amer Bralić, Muhammad Tehseen, Mohamed A Sobhy, Chi-Lin Tsai, Lubna Alhudhali, Gang Yi, Jina Yu, Chunli Yan, Ivaylo Ivanov, Susan E Tsutakawa, John A Tainer, and Samir M Hamdan

Nucleic Acids Research, gkac1095, https://doi.org/10.1093/nar/gkac1095

Origins of transfer establish networks of functional dependencies for plasmid transfer by conjugation

Manuel Ares-Arroyo, Charles Coluzzi, and Eduardo P.C. Rocha

Nucleic Acids Research, gkac1079, https://doi.org/10.1093/nar/gkac1079

Internal RNA 2′O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect

Priscila El Kazzi, Nadia Rabah, Célia Chamontin, Lina Poulain, François Ferron, Françoise Debart, Bruno Canard, Dorothée Missé, Bruno Coutard, Sébastien Nisole, Etienne Decroly

Nucleic Acids Research, gkac996, https://doi.org/10.1093/nar/gkac996

Structural basis for topological regulation of Tn3 resolvase

Sherwin P Montaño, Sally-J Rowland, James R Fuller, Mary E Burke, Alasdair I MacDonald, Martin R Boocock, W Marshall Stark, Phoebe A Rice

Nucleic Acids Research, gkac733, https://doi.org/10.1093/nar/gkac733

Onepot-Seq: capturing single-cell transcriptomes simultaneously in a continuous medium via transient localization of mRNA

Dongju Shin, Jungwon Choi, Ji Hyun Lee, Duhee Bang

Nucleic Acids Research, gkac665, https://doi.org/10.1093/nar/gkac665

Enhanced exon skipping and prolonged dystrophin restoration achieved by TfR1-targeted delivery of antisense oligonucleotide using FORCE conjugation in mdx mice

Cody A Desjardins, Monica Yao, John Hall, Emma O’Donnell, Reshmii Venkatesan, Sean Spring, Aiyun Wen, Nelson Hsia, Peiyi Shen, Ryan Russo, Bo Lan, Tyler Picariello, Kim Tang, Timothy Weeden, Stefano Zanotti, Romesh Subramanian, Oxana Ibraghimov-Beskrovnay

Nucleic Acids Research, gkac641, https://doi.org/10.1093/nar/gkac641

The S. cerevisiae m6A-reader Pho92 promotes timely meiotic recombination by controlling key methylated transcripts

Jérémy Scutenaire, Damien Plassard, Mélody Matelot, Tommaso Villa, Julie Zumsteg, Domenico Libri, Bertrand Séraphin

Nucleic Acids Research, gkac640, https://doi.org/10.1093/nar/gkac640

Construction of a cross-species cell landscape at single-cell level

Renying Wang, Peijing Zhang, Jingjing Wang, Lifeng Ma, Weigao E, Shengbao Suo, Mengmeng Jiang, Jiaqi Li, Haide Chen, Huiyu Sun, Lijiang Fei, Ziming Zhou, Yincong Zhou, Yao Chen, Weiqi Zhang, Xinru Wang, Yuqing Mei, Zhongyi Sun, Chengxuan Yu, Jikai Shao, Yuting Fu, Yanyu Xiao, Fang Ye, Xing Fang, Hanyu Wu, Qile Guo, Xiunan Fang, Xia Li, Xianzhi Gao, Dan Wang, Peng-Fei Xu, Rui Zeng, Gang Xu, Lijun Zhu, Lie Wang, Jing Qu, Dan Zhang, Hongwei Ouyang, He Huang, Ming Chen, Shyh-Chang NG, Guang-Hui Liu, Guo-Cheng Yuan, Guoji Guo, Xiaoping Han

Nucleic Acids Research, gkac633, https://doi.org/10.1093/nar/gkac633

Uncovering translation roadblocks during the development of a synthetic tRNA

Arjun Prabhakar, Natalie Krahn, Jingji Zhang, Oscar Vargas-Rodriguez, Miri Krupkin, Ziao Fu, Francisco J Acosta-Reyes, Xueliang Ge, Junhong Choi, Ana Crnković, Måns Ehrenberg, Elisabetta Viani Puglisi, Dieter Söll, Joseph Puglisi

Nucleic Acids Research, gkac576, https://doi.org/10.1093/nar/gkac576

A transformation clustering algorithm and its application in polyribosomes structural profiling

Wenhong Jiang, Jonathan Wagner, Wenjing Du, Juergen Plitzko, Wolfgang Baumeister, Florian Beck, Qiang Guo

Nucleic Acids Research, gkac547, https://doi.org/10.1093/nar/gkac547

De novo sequencing, diploid assembly, and annotation of the black carpenter ant, Camponotus pennsylvanicus, and its symbionts by one person for $1000, using nanopore sequencing

Christopher Faulk

Nucleic Acids Research, gkac510, https://doi.org/10.1093/nar/gkac510

rRNA operon multiplicity as a bacterial genome stability insurance policy

Sebastien Fleurier, Tanja Dapa, Olivier Tenaillon, Ciarán Condon, Ivan Matic

Nucleic Acids Research, gkac332, https://doi.org/10.1093/nar/gkac332

YY1 safeguard multidimensional epigenetic landscape associated with extended pluripotency

Xiaotao Dong, Rong Guo, Tianrong Ji, Jie Zhang, Jun Xu, Yaoyi Li, Yingliang Sheng, Yuxiang Wang, Ke Fang, Yulin Wen, Bei Liu, Gongcheng Hu, Hongkui Deng, Hongjie Yao

Nucleic Acids Research, gkac230, https://doi.org/10.1093/nar/gkac230

Identification of mechanism of cancer-cell-specific reactivation of hTERT offers therapeutic opportunities for blocking telomerase specifically in human colorectal cancer

Semih Can Akıncılar, Joelle Yi Heng Chua, Qin Feng Ng, Claire Hian Tzer Chan, Zahra Eslami-S, Kaijing Chen, Joo-Leng Low, Surendar Arumugam, Luay Aswad, Clarinda Chua, Iain Beehuat Tan, Ramanuj DasGupta, Melissa Jane Fullwood, Vinay Tergaonkar

Nucleic Acids Research, gkac479, https://doi.org/10.1093/nar/gkac479

A transcriptional roadblock protects yeast centromeres

Sabrine Hedouin, Glennis A Logsdon, Jason G Underwood, Sue Biggins

Nucleic Acids Research, gkac117, https://doi.org/10.1093/nar/gkac117

Cotranscriptional RNA strand exchange underlies the gene regulation mechanism in a purine-sensing transcriptional riboswitch

Luyi Cheng, Elise N White, Naomi L Brandt, Angela M Yu, Alan A Chen, Julius B Lucks

Nucleic Acids Research, gkac102, https://doi.org/10.1093/nar/gkac102

RbgA ensures the correct timing in the maturation of the 50S subunits functional sites

Amal Seffouh, Chirstian Trahan, Tanzila Wasi, Nikhil Jain, Kaustuv Basu, Robert A Britton, Marlene Oeffinger, Joaquin Ortega

Nucleic Acids Research, gkac059, https://doi.org/10.1093/nar/gkac059

Deficiency of ribosomal proteins reshapes the transcriptional and translational landscape in human cells

Yizhao Luan, Nan Tang, Jiaqi Yang, Shuting Liu, Chichi Cheng, Yan Wang, Congying Chen, Ya-nan Guo, Hongwei Wang, Wenxue Zhao, Qian Zhao, Wei Li, Mengqing Xiang, Rong Ju, Zhi Xie

Nucleic Acids Research, gkac053, https://doi.org/10.1093/nar/gkac053

Impact of guanidine-containing backbone linkages on stereopure antisense oligonucleotides in the CNS

Pachamuthu Kandasamy, Yuanjing Liu, Vincent Aduda, Sandheep Akare, Rowshon Alam, Amy Andreucci, David Boulay, Keith Bowman, Michael Byrne, Megan Cannon, Onanong Chivatakarn, Juili Dilip Shelke, Naoki Iwamoto, Tomomi Kawamoto, Jayakanthan Kumarasamy, Sarah Lamore, Muriel Lemaitre, Xuena Lin, Kenneth Longo, Richard Looby, Subramanian Marappan, Jake Metterville, Susovan Mohapatra, Bridget Newman, Ik-Hyeon Paik, Saurabh Patil, Erin Purcell-Estabrook, Mamoru Shimizu, Pochi Shum, Stephany Standley, Kris Taborn, Snehlata Tripathi, Hailin Yang, Yuan Yin, Xiansi Zhao, Elena Dale, Chandra Vargeese

Nucleic Acids Research, gkac037, https://doi.org/10.1093/nar/gkac037

The consequences of differential origin licensing dynamics in distinct chromatin environments

Liu Mei, Katarzyna M Kedziora, Eun-Ah Song, Jeremy E Purvis, Jeanette Gowen Cook

Nucleic Acids Research, gkac003, https://doi.org/10.1093/nar/gkac003

A phage parasite deploys a nicking nuclease effector to inhibit viral host replication

Kristen N LeGault, Zachary K Barth, Peter DePaola, IV, Kimberley D Seed

Nucleic Acids Research, gkac002, https://doi.org/10.1093/nar/gkac002