Zhiqing Diao, Qianzhao Ji, Zeming Wu, Weiqi Zhang, Yusheng Cai, Zehua Wang, Jianli Hu, Zunpeng Liu, Qiaoran Wang, Shijia Bi, Daoyuan Huang, Zhejun Ji, Guang-Hui Liu, Si Wang, Moshi Song, and Jing Qu
Nucleic Acids Research, gkab161, doi: 10.1093/nar/gkab161
As a mammalian Sirtuin, SIRT3 is found primarily in the mitochondria where it plays a crucial role in mitochondrial homeostasis and metabolic modulation. However, the function and mechanism of SIRT3 in regulating human stem cell senescence remain largely unknown. Here, investigators describe a novel role for SIRT3 as a regulator of heterochromatin organization, thereby safeguarding hMSCs from senescence. Their mechanistic investigations reveal that SIRT3 coordinates with heterochromatin proteins and lamina-associated proteins in the nucleus to maintain heterochromatin stability and repress the activation of repetitive sequences.