Genome-wide mapping of SARS-CoV-2 RNA structures identifies therapeutically-relevant elements

Ilaria Manfredonia, Chandran Nithin, Almudena Ponce-Salvatierra, Pritha Ghosh, Tomasz K Wirecki, Tycho Marinus, Natacha S Ogando, Eric J Snijder, Martijn J van Hemert, Janusz M Bujnicki, and Danny Incarnato

Nucleic Acids Research, gkaa1183,

Multiple outbreaks of severe acute respiratory syndromes caused by coronaviruses over the past 18 years, the latest leading to (as of this writing) nearly one million deaths across the world, have demonstrated the pressing need for new therapeutically-relevant and durable druggable targets for the treatment of coronavirus infections. This paper describes the characterization of the SARS-CoV-2 RNA genome structure using a variety of experimental and computational methods.

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