Contribution of DNA adenine methylation to gene expression heterogeneity in Salmonella enterica

María A Sánchez-Romero, David R Olivenza, Gabriel Gutiérrez, and Josep Casadesús

Nucleic Acids Research, gkaa730,

In this study, the authors describe how epigenetic mechanisms produce cell-to-cell variations of gene expression that may benefit bacterial populations by generating phenotypic diversity. The authors investigated this topic by studying Dam methylase dependent bistable gene regulation in Salmonella. They identified patterns of gene regulation dependent upon several undermethylated Dam sites, confirmed the dependence on DNA adenine methylation and environmental conditions, identified responsible DNA binding proteins, and showed independent switching of different genes.

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