2019 Breakthrough Articles

GLP-catalyzed H4K16me1 promotes 53BP1 recruitment to permit DNA damage repair and cell survival

Xiaopeng Lu, Ming Tang, Qian Zhu, Qiaoyan Yang, Zhiming Li, Yantao Bao, Ge Liu, Tianyun Hou, Yafei Lv, Ying Zhao, Haiying Wang, Yang Yang, Zhongyi Cheng, He Wen, Baohua Liu, Xingzhi Xu, Luo Gu, and Wei-Guo Zhu

Nucleic Acids Res (2019) 47(21): 10977–10993. doi:10.1093/nar/gkz897

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Global analysis of protein synthesis in Flavobacterium johnsoniae reveals the use of Kozak-like sequences in diverse bacteria

William D Baez, Bappaditya Roy, Zakkary A McNutt, Elan A Shatoff, Shicheng Chen, Ralf Bundschuh, and Kurt Fredrick

Nucleic Acids Res (2019) 47 (20): 10477–10488. doi:10.1093/nar/gkz855

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The ABCD database: a repository for chemically defined antibodies

Wanessa C Lima, Elisabeth Gasteiger, Paolo Marcatili, Paula Duek, Amos Bairoch, and Pierre Cosson

Nucleic Acids Res (2019) 48 (D1): D261-D264. doi:10.1093/nar/gkz827

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DNA-PKcs promotes chromatin decondensation to facilitate initiation of the DNA damage response

Huiming Lu, Janapriya Saha, Pauline J Beckmann, Eric A Hendrickson, and Anthony J Davis

Nucleic Acids Res (2019) 47(18): 9467–9479. doi:10.1093/nar/gkz694

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CtIP is essential for telomere replication

Susanna Stroik, Kevin Kurtz, and Eric A Hendrickso

Nucleic Acids Res (2019) 47(17): 8927–8940. doi:10.1093/nar/gkz652

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Single-molecule visualization reveals the damage search mechanism for the human NER protein XPC-RAD23B

Na Young Cheon, Hyun-Suk Kim, Jung-Eun Yeo, Orlando D Schärer, and Ja Yil Lee

Nucleic Acids Res. (2019) 47(16): 8337-8347. doi:10.1093/nar/gkz629

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The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112

Nhan van Tran, Felix G M Ernst, Ben R Hawley, Christiane Zorbas, Nathalie Ulryck, Philipp Hackert, Katherine E Bohnsack, Markus T Bohnsack, Samie R Jaffrey, Marc Graille and Denis L J Lafontaine

Nucleic Acids Res. (2019) 47(15): 7719-7733. doi:10.1093/nar/gkz619

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Structural intermediates of a DNA–ligase complex illuminate the role of the catalytic metal ion and mechanism of phosphodiester bond formation

Adele Williamson, Hanna-Kirsti S Leiros

Nucleic Acids Res (2019) 47(14): 7147-7162. doi:10.1093/nar/gkz596

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Structure and mechanism of pyrimidine–pyrimidone (6-4) photoproduct recognition by the Rad4/XPC nucleotide excision repair complex

Debamita Paul, Hong Mu, Hong Zhao, Ouathek Ouerfelli, Philip D Jeffrey, Suse Broyde and Jung-Hyun Min

Nucleic Acids Res (2019) 47(12): 6015–6028. doi:10.1093/nar/gkz359

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Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins

Michael T. Migawa, Wen Shen, W. Brad Wan, Guillermo Vasquez, Michael E. Oestergaard, Audrey Low, Cheryl L. De Hoyos, Ruchi Gupta, Susan Murray, Michael Tanowitz, Melanie Bell, Joshua G. Nichols, Hans Gaus, Xue-hai Liang, Eric E. Swayze, Stanley T. Crooke and Punit P. Seth

Nucleic Acids Res (2019) 47(11): 5465–5479. doi:10.1093/nar/gkz247

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The nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair

Naike Salvador Moreno, Jing Liu, Karen M Haas, Laurie L Parker, Chaitali Chakraborty, Stephen J Kron, Kurt Hodges, Lance D Miller, Carl Langefeld, Paul J Robinson, Sophie A Lelièvre, and Pierre-Alexandre Vidi

Nucleic Acids Res (2019) 47(6): 2703–2715. doi:10.1093/nar/gkz138

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ViBrism DB: an interactive search and viewer platform for 2D/3D anatomical images of gene expression and co-expression networks

Masahiko Morita, Kazuro Shimokawa, Masaomi Nishimura, Sakiko Nakamura, Yuki Tsujimura, Satoko Takemoto, Takehiro Tawara, Hideo Yokota, Shuhei Wemler, Daisuke Miyamoto, Hidetoshi Ikeno, Akira Sato, Teiichi Furuichi, Norio Kobayashi, Yoshihiro Okumura, Yoko Yamaguchi, and Yuko Okamura-Oho

Nucleic Acids Res (2019) 47(D1): D859–D866. doi:10.1093/nar/gky951

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The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease

Alberto Noronha, Jennifer Modamio, Yohan Jarosz, Elisabeth Guerard, Nicolas Sompairac, German Preciat, Anna Dröfn Daníelsdóttir, Max Krecke, Diane Merten, Hulda S Haraldsdóttir, Almut Heinken, Laurent Heirendt, Stefanía Magnúsdóttir, Dmitry A Ravcheev, Swagatika Sahoo, Piotr Gawron, Lucia Friscioni, Beatriz Garcia, Mabel Prendergast, Alberto Puente, Mariana Rodrigues. Akansha Roy, Mouss Rouquaya, Luca Wiltgen, Alise Žagare, Elisabeth John, Maren Krueger, Inna Kuperstein, Andrei Zinovyev, Reinhard Schneider, Ronan M T Fleming, and Ines Thiele

Nucleic Acids Res (2019) 47 (D1): D614–D624. doi:10.1093/nar/gky992

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Inosine induces context-dependent recoding and translational stalling

Konstantin Licht, Markus Hartl, Fabian Amman, Dorothea Anrather, Michael P Janisiw. and Michael F Jantsch

Nucleic Acids Res (2019) 47 (1): 3–14. doi:10.1093/nar/gky1163

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