2018 Breakthrough Articles

Metabolic and chemical regulation of tRNA modification associated with taurine deficiency and human disease

Kana Asano, Takeo Suzuki, Ayaka Saito, Fan-Yan Wei, Yoshiho Ikeuchi, Tomoyuki Numata, Ryou Tanaka. Yoshihisa Yamane, Takeshi Yamamoto, Takanobu Goto, Yoshihito Kishita, Kei Murayama, Akira Ohtake, Yasushi Okazaki, Kazuhito Tomizawa, Yuriko Sakaguchi and Tsutomu Suzuki

Nucleic Acids Research (2018) 46(4): 1565–1583. doi:10.1093/nar/gky068

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The mechanisms of a mammalian splicing enhancer

Andrew M Jobbins, Linus F Reichenbach, Christian M Lucas, Andrew J Hudson, Glenn A Burley and Ian C Eperon

Nucleic Acids Res (2018) 46 (5): 2145–2158. doi:10.1093/nar/gky056

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An interplay of miRNA abundance and target site architecture determines miRNA activity and specificity

Giovanna Brancati, Helge Großhans

Nucleic Acids Res (2018) 46(7):3259–3269. doi:10.1093/nar/gky201

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Extensive and systematic rewiring of histone post-translational modifications in cancer model systems

Roberta Noberini, Daniela Osti, Claudia Miccolo, Cristina Richichi, Michela Lupia, Giacomo Corleone, Sung-Pil Hong, Piergiuseppe Colombo, Bianca Pollo, Lorenzo Fornasari, Giancarlo Pruneri, Luca Magnani, Ugo Cavallaro, Susanna Chiocca, Saverio Minucci, Giuliana Pelicci and Tiziana Bonaldi

Nucleic Acids Res (2018) 46(8): 3817–3832. doi:10.1093/nar/gky224

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The arginine methyltransferase CARM1 represses p300•ACT•CREMτ activity and is required for spermiogenesis

Jianqiang Bao, Sophie Rousseaux, Jianjun Shen, Kevin Lin, Yue Lu and Mark T Bedford

Nucleic Acids Res (2018) 46(9): 4327–4343. doi:10.1093/nar/gky240

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Antisense oligonucleotides correct the familial dysautonomia splicing defect in IKBKAP transgenic mice

Rahul Sinha, Young Jin Kim, Tomoki Nomakuchi, Kentaro Sahashi, Yimin Hua, Frank Rigo, C Frank Bennett and Adrian R Krainer

Nucleic Acids Research (2018) 46(10): 4833–4844. doi:10.1093/nar/gky249

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Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction

Jithesh Kottur, Deepak T Nair

Nucleic Acids Res (2018) 46(12): 5875–5885, doi:10.1093/nar/gky402

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Structure of HIV TAR in complex with a Lab-Evolved RRM provides insight into duplex RNA recognition and synthesis of a constrained peptide that impairs transcription

Ivan A Belashov, David W Crawford, Chapin E Cavender, Peng Dai, Patrick C Beardslee, David H Mathews, Bradley L Pentelute, Brian R McNaughton, Joseph E Wedekind

Nucleic Acids Res (2018) 46(13): 6401–6415, doi:10.1093/nar/gky529

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Generating genomic platforms to study <i>Candida albicans</i> pathogenesis

Mélanie Legrand, Sophie Bachellier-Bassi, Keunsook K. Lee, Yogesh Chaudhari, Hélène Tournu, Laurence Arbogast, Hélène Boyer, Murielle Chauvel, Vitor Cabral, Corinne Maufrais, Audrey Nesseir, Irena Maslanka, Emmanuelle Permal, Tristan Rossignol, Louise A. Walker, Ute Zeidler, Sadri Znaidi, Floris Schoeters, Charlotte Majgier, Renaud A. Julien, Laurence Ma, Magali Tichit, Christiane Bouchier, Patrick V. Dijck, Carol A. Munro and Christophe d’Enfert

Nucleic Acids Res (2018) 46(21): 11129–11143. doi:10.1093/nar/gky920

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3′ end additions by T7 RNA polymerase are RNA self-templated, distributive and diverse in character—RNA-Seq analyses

Yasaman Gholamalipour, Aruni Karunanayake Mudiyanselage and Craig T Martin

Nucleic Acids Res (2018) 46(18): 9253–9263. doi:10.1093/nar/gky796

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Recombination is required for efficient HIV-1 replication and the maintenance of viral genome integrity

Jonathan M.O. Rawson, Olga A. Nikolaitchik, Brandon F. Keele, Vinay K. Pathak, Wei-Shau Hu

Nucleic Acids Res (2018) 46(20):10535–10545. doi:10.1093/nar/gky910

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Crosstalk among Set1 complex subunits involved in H2B ubiquitylation-dependent H3K4 methylation

Jongcheol Jeon, Robert K McGinty, Tom W Muir, Jung-Ae Kim and Jaehoon Kim

Nucleic Acids Res (2018) 46 (21): 11129–11143. doi:10.1093/nar/gky920

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Single-nucleotide-resolution sequencing of human N 6 -methyldeoxyadenosine reveals strand-asymmetric clusters associated with SSBP1 on the mitochondrial genome

Casslynn W Q Koh, Yeek Teck Goh, Joel D W Toh, Suat Peng Neo, Sarah B Ng, Jayantha Gunaratne, Yong-Gui Gao, Stephen R Quake, William F Burkholder, and Wee Siong S Goh

Nucleic Acids Res (2018) 46 (22): 11659–11670. doi:10.1093/nar/gky1104

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