2017 Breakthrough Articles

Prespacer processing and specific integration in a Type I-A CRISPR system

Clare Rollie, Shirley Graham, Christophe Rouillon and Malcolm F. White
Nucleic Acids Res (2018) 46(3): 1007–1020, doi:10.1093/nar/gkx1232
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Reconstitution of the CstF complex unveils a regulatory role for CstF-50 in recognition of 3′-end processing signals

Wen Yang, Peter L. Hsu, Fan Yang, Jae-Eun Song and Gabriele Varani
Nucleic Acids Res (2018) 46(2): 493–503, doi:10.1093/nar/gkx1177
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Designer tRNAs for efficient incorporation of non-canonical amino acids by the pyrrolysine system in mammalian cells

Robert Serfling, Christian Lorenz, Maja Etzel, Gerda Schicht, Thore Böttke, Mario Mörl and Irene Coin
Nucleic Acids Research (2018) 46 (1): 1–10, doi:10.1093/nar/gkx1156
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Logical engineering of D-arm and T-stem of tRNA that enhances d-amino acid incorporation

Takayuki Katoh, Yoshihiko Iwane, Hiroaki Suga
Nucleic Acids Res (2017) doi:10.1093/nar/gkx1129
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DNA-assisted oligomerization of pore-forming toxin monomers into precisely-controlled protein channels

Anja Henning-Knechtel, Johann Knechtel and Mazin Magzoub
Nucleic Acids Research (2017) doi:10.1093/nar/gkx990
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Measurements of translation initiation from all 64 codons in E. coli

Ariel Hecht, Jeff Glasgow, Paul R. Jaschke, Lukmaan A. Bawazer, Matthew S. Munson, Jennifer R. Cochran, Drew Endy and Marc Salit
Nucleic Acids Research (2017) 45(7): 3615–3626, doi:10.1093/nar/gkx070
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Proteomic identification of histone post-translational modifications and proteins enriched at a DNA double-strand break

Pingping Wang, Stephanie Byrum, Faith C. Fowler, Sangita Pal, Alan J. Tackett and Jessica K. Tyler
Nucleic Acids Res (2017) 45(19): 10923–10940, doi:10.1093/nar/gkx844
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A single active site in the mariner transposase cleaves DNA strands of opposite polarity

Corentin Claeys Bouuaert and Ronald Chalmers
Nucleic Acids Research (2017) 45 (20): 11467–11478. doi:10.1093/nar/gkx826
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Subtelomeres constitute a safeguard for gene expression and chromosome homeostasis

Sanki Tashiro, Yuki Nishihara, Kazuto Kugou, Kunihiro Ohta and Junko Kanoh
Nucleic Acids Res (2017) 45 (18):10333–10349, doi:10.1093/nar/gkx780
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Analysis of in vitro evolution reveals the underlying distribution of catalytic activity among random sequences

Abe Pressman, Janina E. Moretti, Gregory W. Campbell, Ulrich F. Müller and Irene A. Chen
Nucleic Acids Research (2017) 45(14): 8167–8179, doi:10.1093/nar/gkx540
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A snoRNA modulates mRNA 3΄ end processing and regulates the expression of a subset of mRNAs

Chunliu Huang, Junjie Shi, Yibin Guo, Weijun Huang, Shanshan Huang, Siqi Ming, Xingui Wu, Rui Zhang, Junjun Ding, Wei Zhao, Jie Jia, Xi Huang, Andy Peng Xiang, Yongsheng Shi, Chengguo Yao
Nucleic Acids Research (2017) 45(15) 8647–8660. doi:10.1093/nar/gkx651
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Features of genomic organization in a nucleotide-resolution molecular model of the Escherichia coli chromosome

William C. Hacker, Shuxiang Li, Adrian H. Elcock
Nucleic Acids Research (2017) 45 (13): 7541–7554. doi: 10.1093/nar/gkx541
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The CDI toxin of Yersinia kristensenii is a novel bacterial member of the RNase A superfamily

Gaëlle Batot, Karolina Michalska, Greg Ekberg, Ervin M. Irimpan, Grazyna Joachimiak, Robert Jedrzejczak, Gyorgy Babnigg, Christopher S. Hayes, Andrzej Joachimiak, and Celia W. Goulding
Nucleic Acids Research, Volume 45 (9) 5013–5025, doi: 10.1093/nar/gkx230
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CTC1-mediated C-strand fill-in is an essential step in telomere length maintenance

Xuyang Feng, Shih-Jui Hsu, Christopher Kasbek, Mary Chaiken, Carolyn M. Price
Nucleic Acids Res 2017; 45 (8): 4281-4293. doi: 10.1093/nar/gkx125
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Molecular mechanism governing ratio-dependent transcription regulation in the ccdAB operon

Alexandra Vandervelde, Igor Drobnak, San Hadži, Yann G.-J. Sterckx, Thomas Welte, Henri De Greve, Daniel Charlier, Rouslan Efremov, Remy Loris, Jurij Lah
Nucleic Acids Research (2017) doi:10.1093/nar/gkx108
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Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETS factors ETV1, ETV4 and ETV5

Simon L. Currie, Desmond K. W. Lau, Jedediah J. Doane, Frank G. Whitby, Mark Okon, Lawrence P. McIntosh, and Barbara J. Graves
Nucleic Acids Res (2017) 45 (5): 2223-2241. doi: 10.1093/nar/gkx068
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Non-canonical targets destabilize microRNAs in human Argonautes

June Hyun Park, Sang-Yoon Shin and Chanseok Shin
Nucleic Acids Res (2017) 45 (4): 1569-1583. doi:10.1093/nar/gkx029
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