2016 Breakthrough Articles

The Monarch Initiative: an integrative data and analytic platform connecting phenotypes to genotypes across species

Christopher J. Mungall, Julie A. McMurry, Sebastian Köhler, James P. Balhoff, Charles Borromeo, Matthew Brush, Seth Carbon, Tom Conlin, Nathan Dunn et al.
Nucleic Acids Res (2017) 45 (D1): D712-D722. doi:10.1093/nar/gkw1128
Free Full Text

Open Targets: a platform for therapeutic target identification and validation

Nikiforos Karamanis, Michael Maguire, Eliseo Papa, Andrea Pierleoni, Miguel Pignatelli, Theo Platt, Francis Rowland, Priyanka Wankar, A. Patrícia Bento, Tony Burdett, Antonio Fabregat, Simon Forbes, Anna Gaulton, Cristina Yenyxe Gonzalez, Henning Hermjakob, Anne Hersey, Steven Jupe, Şenay Kafkas, Maria Keays et al.
Nucleic Acids Res (2016) 45 (D1): D985-D994. doi:10.1093/nar/gkw1055
Free Full Text

denovo-db: a compendium of human de novo variants

Tychele N. Turner, Qian Yi, Niklas Krumm, John Huddleston, Kendra Hoekzema, Holly A. F. Stessman, Anna-Lisa Doebley, Raphael A. Bernier, Deborah A. Nickerson and Evan E. Eichler
Nucl. Acids Res. (2016) 45 (D1): D804-D811 doi: 10.1093/nar/gkw865
Free Full Text

Division of labor among Mycobacterium smegmatis RNase H enzymes: RNase H1 activity of RnhA or RnhC is essential for growth whereas RnhB and RnhA guard against killing by hydrogen peroxide in stationary phase

Richa Gupta, Debashree Chatterjee, Michael S. Glickman and Stewart Shuman
Nucl. Acids Res. (2016) doi: 10.1093/nar/gkw1046
Free Full Text

Antisense oligonucleotides delivered to the amniotic cavity in utero modulate gene expression in the postnatal mouse

Frederic F. Depreux, Lingyan Wang, Han Jiang, Francine M. Jodelka, Robert F. Rosencrans, Frank Rigo, Jennifer J. Lentz, John V. Brigande and Michelle L. Hastings
Nucl. Acids Res. (2016) 44 (20): 9519-9529. doi: 10.1093/nar/gkw867
Free Full Text

Mitochondrial DNA exhibits resistance to induced point and deletion mutations

William J. Valente, Nolan G. Ericson, Alexandra S. Long, Paul A. White, Francesco Marchetti and Jason H. Bielas
Nucl. Acids Res. (2016) doi: 10.1093/nar/gkw716
Free Full Text

High-resolution structure of the presynaptic RAD51 filament on single-stranded DNA by electron cryo-microscopy

Judith M. Short, Yang Liu, Shaoxia Chen, Neelesh Soni, Mallur S. Madhusudhan, Mahmud K.K. Shivji and Ashok R. Venkitaraman
Nucl. Acids Res. (2016) doi: 10.1093/nar/gkw783
Free Full Text

3.9 Å structure of the nucleosome core particle determined by phase-plate cryo-EM

Eugene Y.D. Chua, Vinod K. Vogirala, Oviya Inian, Andrew S.W. Wong, Lars Nordenskiöld, Juergen M. Plitzko, Radostin Danev and Sara Sandin
Nucl. Acids Res. (2016) doi: 10.1093/nar/gkw708
Free Full Text

Reversible acetylation on Lys501 regulates the activity of RNase II

Limin Song, Guangyuan Wang, Arun Malhotra, Murray P. Deutscher and Wenxing Liang
Nucl. Acids Res. 44 (5): 1979-1988. doi: 10.1093/nar/gkw053
Free Full Text

A novel role for poly(C) binding proteins in programmed ribosomal frameshifting

Sawsan Napthine, Emmely E. Treffers, Susanne Bell, Ian Goodfellow, Ying Fang, Andrew E. Firth, Eric J. Snijder, and Ian Brierley
Nucl. Acids Res. (2016) 44 (12): 5491-5503. doi: 10.1093/nar/gkw480
Free Full Text

The STAR protein QKI-7 recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs

Ryota Yamagishi, Takeshi Tsusaka, Hiroko Mitsunaga, Takaharu Maehata and Shin-ichi Hoshino
Nucl. Acids Res. (2016) 44 (6): 2475-2490. doi: 10.1093/nar/gkw118
Free Full Text

Identification of a mismatch-specific endonuclease in hyperthermophilic Archaea

Sonoko Ishino, Yuki Nishi, Soichiro Oda, Takashi Uemori, Takehiro Sagara, Nariaki Takatsu, Takeshi Yamagami, Tsuyoshi Shirai and Yoshizumi Ishino
Nucl. Acids Res. (2016) 44 (7): 2977-2986. doi: 10.1093/nar/gkw153
Free Full Text