2014 Breakthrough Articles

Genome-wide analyses of LINE–LINE-mediated nonallelic homologous recombination

Michał Startek, Przemyslaw Szafranski, Tomasz Gambin, Ian M. Campbell, Patricia Hixson, Chad A. Shaw, Paweł Stankiewicz and Anna Gambin

Nucl. Acids Res. (27 February 2015) 43 (4): 2188-2198. doi: 10.1093/nar/gku1394

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A systematic survey of the Cys2His2 zinc finger DNA-binding landscape

Anton V. Persikov, Joshua L. Wetzel, Elizabeth F. Rowland, Benjamin L. Oakes, Denise J. Xu, Mona Singh and Marcus B. Noyes

Nucl. Acids Res. (18 February 2015) 43 (3): 1965-1984. doi: 10.1093/nar/gku1395

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Chromosome conformation maps in fission yeast reveal cell cycle dependent sub nuclear structure

Ralph S. Grand, Tatyana Pichugina, Lutz R. Gehlen, M. Beatrix Jones, Peter Tsai, Jane R. Allison, Robert Martienssen and Justin M. O’Sullivan

Nucl. Acids Res. (10 November 2014) 42 (20): 12585-12599. doi: 10.1093/nar/gku965

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Paramecium tetraurelia chromatin assembly factor-1-like protein PtCAF-1 is involved in RNA-mediated control of DNA elimination

Michael Ignarski, Aditi Singh, Estienne C. Swart, Miroslav Arambasic, Pamela Y. Sandoval and Mariusz Nowacki

Nucl. Acids Res. (29 October 2014) 42 (19): 11952-11964. doi: 10.1093/nar/gku874

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Mechanism of retinoic acid-induced transcription: histone code, DNA oxidation and formation of chromatin loops

Candida Zuchegna, Fabiana Aceto, Alessandra Bertoni, Antonella Romano, Bruno Perillo, Paolo Laccetti, Max E. Gottesman, Enrico V. Avvedimento and Antonio Porcellini

Nucl. Acids Res. (29 September 2014) 42 (17): 11040-11055. doi: 10.1093/nar/gku823

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Direct entry by RNase E is a major pathway for the degradation and processing of RNA in Escherichia coli

Justin E. Clarke, Louise Kime, David Romero A. and Kenneth J. McDowall

Nucl. Acids Res. (13 October 2014) 42 (18): 11733-11751. doi: 10.1093/nar/gku808

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Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1

Eric J. Montemayor, Adam Katolik, Nathaniel E. Clark, Alexander B. Taylor, Jonathan P. Schuermann, D. Joshua Combs, Richard Johnsson, Stephen P. Holloway, Scott W. Stevens, Masad J. Damha and P. John Hart

Nucl. Acids Res. (15 September 2014) 42 (16): 10845-10855. doi: 10.1093/nar/gku725

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7SL RNA represses p53 translation by competing with HuR

Kotb Abdelmohsen, Amaresh C. Panda, Min-Ju Kang, Rong Guo, Jiyoung Kim, Ioannis Grammatikakis, Je-Hyun Yoon, Dawood B. Dudekula, Ji Heon Noh, Xiaoling Yang, Jennifer L. Martindale and Myriam Gorospe

Nucl. Acids Res. (2 September 2014) 42 (15): 10099-10111. doi: 10.1093/nar/gku686

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A dimeric state for PRC2

Chen Davidovich, Karen J. Goodrich, Anne R. Gooding and Thomas R. Cech

Nucl. Acids Res. (18 August 2014) 42 (14): 9236-9248. doi: 10.1093/nar/gku540

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Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice

Thazha P. Prakash, Mark J. Graham, Jinghua Yu, Rick Carty, Audrey Low, Alfred Chappell, Karsten Schmidt, Chenguang Zhao, Mariam Aghajan, Heather F. Murray, Stan Riney, Sheri L. Booten, Susan F. Murray, Hans Gaus, Jeff Crosby, Walt F. Lima, Shuling Guo, Brett P. Monia, Eric E. Swayze and Punit P. Seth

Nucl. Acids Res. (29 July 2014) 42 (13): 8796-8807. doi: 10.1093/nar/gku531

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Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters

Jayne Loughery, Miranda Cox, Linda M. Smith and David W. Meek

Nucl. Acids Res. (8 July 2014) 42 (12): 7666-7680. doi: 10.1093/nar/gku501

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PARP-2 and PARP-3 are selectively activated by 5′ phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1

Marie-France Langelier, Amanda A. Riccio and John M. Pascal

Nucl. Acids Res. (8 July 2014) 42 (12): 7762-7775. doi: 10.1093/nar/gku474

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HIV-1 Rev protein specifies the viral RNA export pathway by suppressing TAP/NXF1 recruitment

Ichiro Taniguchi, Naoto Mabuchi and Mutsuhito Ohno

Nucl. Acids Res. (02 June 2014) 42 (10): 6645-6658. doi: 10.1093/nar/gku304

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Crystal structure of a 4-thiouridine synthetase–RNA complex reveals specificity of tRNA U8 modification

Piotr Neumann, Kristina Lakomek, Peter-Thomas Naumann, Whitney M. Erwin, Charles T. Lauhon and Ralf Ficner

Nucl. Acids Res. (02 June 2014) 42 (10): 6673-6685. doi: 10.1093/nar/gku249

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Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation

WeiShen Aik, John S. Scotti, Hwanho Choi, Lingzhi Gong, Marina Demetriades, Christopher J. Schofield and Michael A. McDonough

Nucl. Acids Res. (2014) 42 (7): 4741-4754. doi: 10.1093/nar/gku085

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