2013 Breakthrough Articles

A dynamic alternative splicing program regulates gene expression during terminal erythropoiesis

Harold Pimentel, Marilyn Parra, Sherry Gee, Dana Ghanem, Xiuli An, Jie Li, Narla Mohandas, Lior Pachter and John G. Conboy

Nucl. Acids Res. (2014) 42 (6): 4031-4042. doi: 10.1093/nar/gkt1388

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Three-tiered role of the pioneer factor GATA2 in promoting androgen-dependent gene expression in prostate cancer

Dayong Wu, Benjamin Sunkel, Zhong Chen, Xiangtao Liu, Zhenqing Ye, Qianjin Li, Cassandra Grenade, Jingdong Ke, Chunpeng Zhang, Hongyan Chen, Kenneth P. Nephew, Tim H.-M. Huang, Zhihua Liu, Victor X. Jin and Qianben Wang

Nucl. Acids Res. (2014) 42 (6): 3607-3622. doi: 10.1093/nar/gkt1382

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The Vertebrate Genome Annotation browser 10 years on

Jennifer L. Harrow, Charles A. Steward, Adam Frankish, James G. Gilbert, Jose M. Gonzalez, Jane E. Loveland, Jonathan Mudge, Dan Sheppard, Mark Thomas, Stephen Trevanion and Laurens G. Wilming

Nucl. Acids Res. (1 January 2014) 42 (D1): D771-D779. doi: 10.1093/nar/gkt1241

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Cycling of the E. coli lagging strand polymerase is triggered exclusively by the availability of a new primer at the replication fork

Quan Yuan and Charles S. McHenry

Nucl. Acids Res. (2014) 42 (3): 1747-1756. doi: 10.1093/nar/gkt1098

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TFBSshape: a motif database for DNA shape features of transcription factor binding sites

Lin Yang, Tianyin Zhou, Iris Dror, Anthony Mathelier, Wyeth W. Wasserman, Raluca Gordân and Remo Rohs

Nucl. Acids Res. (1 January 2014) 42 (D1): D148-D155. doi: 10.1093/nar/gkt1087

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The double PHD finger domain of MOZ/MYST3 induces α-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification

Ingrid Dreveny, Sian E. Deeves, Joel Fulton, Baigong Yue, Marie Messmer, Amit Bhattacharya, Hilary M. Collins and David M. Heery

Nucl. Acids Res. (2014) 42 (2): 822-835. doi: 10.1093/nar/gkt931

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Co-regulated gene expression by oestrogen receptor α and liver receptor homolog-1 is a feature of the oestrogen response in breast cancer cells

Chun-Fui Lai, Koen D. Flach, Xanthippi Alexi, Stephen P. Fox, Silvia Ottaviani, Paul T.R. Thiruchelvam, Fiona J. Kyle, Ross S. Thomas, Rosalind Launchbury, Hui Hua, Holly B. Callaghan, Jason S. Carroll, R. Charles Coombes, Wilbert Zwart, Laki Buluwela and Simak Ali

Nucl. Acids Res. (2013) 41 (22): 10228-10240. doi: 10.1093/nar/gkt827

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Pre-activation of the genome integrity checkpoint increases DNA damage tolerance

Olga Tsaponina and Andrei Chabes

Nucl. Acids Res. (2013) 41 (22): 10371-10378. doi: 10.1093/nar/gkt820

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Promoter RNA links transcriptional regulation of inflammatory pathway genes

Masayuki Matsui, Yongjun Chu, Huiying Zhang, Keith T. Gagnon, Sarfraz Shaikh, Satya Kuchimanchi, Muthiah Manoharan, David R. Corey and Bethany A. Janowski

Nucl. Acids Res. (2013) 41 (22): 10086-10109. doi: 10.1093/nar/gkt777

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Increasing the complexity of chromatin: functionally distinct roles for replication-dependent histone H2A isoforms in cell proliferation and carcinogenesis

Rajbir Singh, Amir Mortazavi, Kelly H. Telu, Prabakaran Nagarajan, David M. Lucas, Jennifer M. Thomas-Ahner, Steven K. Clinton, John C. Byrd, Michael A. Freitas and Mark R. Parthun

Nucl. Acids Res. (2013) 41 (20): 9284-9295. doi: 10.1093/nar/gkt736

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Helq acts in parallel to Fancc to suppress replication-associated genome instability

Spencer W. Luebben, Tsuyoshi Kawabata, Monica K. Akre, Wai Long Lee, Charles S. Johnson, M. Gerard O’Sullivan and Naoko Shima

Nucl. Acids Res. (2013) 41 (22): 10283-10297. doi: 10.1093/nar/gkt676

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Attachment site recognition and regulation of directionality by the serine integrases

Karen Rutherford, Peng Yuan, Kay Perry, Robert Sharp and Gregory D. Van Duyne

Nucl. Acids Res. (2013) 41 (17): 8341-8356. doi: 10.1093/nar/gkt580

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